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Home > Products > Organic Intermediate > Organic Intermediate ETHYLL-4-CHLORO-3-HYDROXY BUTYRATE CAS 10488-69-4

Organic Intermediate ETHYLL-4-CHLORO-3-HYDROXY BUTYRATE CAS  10488-69-4

Organic Intermediate ETHYLL-4-CHLORO-3-HYDROXY BUTYRATE CAS 10488-69-4

    Payment Type: T/T
    Terms of Trade: CIF
    Min. Order: 1 Kilogram
    Delivery Time: 15 Days
    Packaging: AS REQUIRED
    Productivity: KGS
    Transportation: Air
    Place of Origin: CHINA
    Supply Ability: TRUE MANUFACTURER
    Certificate: ISO

Basic Info

Model No.: 10488-69-4

Product Description

ETHYLL-4-CHLORO-3-HYDROXY BUTYRATE CAS number is 10488-69-4,It is an important Organic Intermediate, Its main use is to synthesize precursor compounds of cholesterol-lowering drugs, but also for many activities Synthesis of drugs such as hydroxymethylglutaryl reductase inhibitors and 1,4-dihydropyridine β-blockers. ETHYLL-4-CHLORO-3-HYDROXY BUTYRATE has the advantage of being easy to synthesize and inexpensive, and it is a very cost-effective way to prepare ETHYLL-4-CHLORO-3-HYDROXY BUTYRATE by asymmetric reduction as a reaction raw material. Moreover, during the reaction, the microorganism does not use the product of the reaction to produce other new impurities, so that the preparation reaction can be carried out by using whole cells of the microorganism, and the reaction method is simpler.
At present, there have been many reports on the preparation of chiral ETHYLL-4-CHLORO-3-HYDROXY BUTYRATE by asymmetric reduction of ethyl 4-chloroacetoacetate. The main preparation methods are chemical methods and biological methods. Among them, microbial catalysis in biological methods is a hot spot of research. Microbial catalysis utilizes the stereoselectivity of a specific microbial cell-specific enzyme system to selectively convert a substrate into a product in a cell. However, due to the complexity of the enzyme system present in the cell, the optical purity of the catalytic product is not high, and it is necessary to screen an excellent microbial strain or to improve by cloning a recombinant gene. Coenzyme addition is also required to provide the reducing power of the reaction.
In the technique of preparing DL-4-chloro-3-hydroxybutyric acid ethyl ester by asymmetric reduction of ethyl 4-chloroacetoacetate by microbial catalytic method, the substrate conversion rate is low, the optical purity of the product is low, and the coenzyme cycle regeneration is solved. Need to be further studied and resolved. Someone specially designed a technical solution for this: using 4-chloroacetoacetate as a substrate, glucose as a substrate, NAD(P)+ as a cofactor, and introducing a ketoreductase gene and glucose dehydrogenation. Recombinant Escherichia coli with the enzyme GDH gene was subjected to a transformation reaction to prepare an asymmetric solution of Ethyll-4-Chloro-3-Hydroxy Butyrate. This method effectively solves various major defects in the asymmetric reduction of Ethyll-4-Chloro-3-Hydroxy Butyrate CAS 10488-69-4 microbial catalytic method.

Thera. Category: Organic intermediate

Cas No.:10488-69-4


Synonym:COBE;ETHYLL-4-CHLORO-3-HYDROXY BUTYRATE;Ethyl-4-Chloro-4-HydroxyButyrate;

Molecular Formula:C6H11ClO3

Molecular Weight:166.60274

Assay: ≥99.%

Packing: Export worthy packing

lMaterial Safety Data Sheet: Available on request

Taizhou Volsen Chemical Co., Ltd.


Taizhou Volsen Chemical Co., Ltd. is professional in R&D, producing and marketing Pharmaceutical raw materials, pharmaceutical intermediates in China. VOLSEN consists of about 100 experienced employees including 3 PhD and 10 Master, and 35000 sqm facilities including research laboratories, kilo lab, pilot plant and full manufacturing plant,

VOLSEN R&D specialists, quality manager and sales with abundance experience make sure products are reliable and service is professional. The producing person inspect every step of the whole process and check up the quality strictly, in order to insure every batch of raw material achieve the standard of EP,CP, JP,BP etc.Matching to the diversified requirements of companies VOLSEN is steadily marching to reach the peaks.

Volsen owns a professional custom synthesis department, with more than 15 senior scientific research chemical personnels who have a graduate degree or above. We also have an independent scientific management system. Our company integrates years of production experiences and talent reserves that forms a strong R&D production capacity, furthermore we could undertake various chemicals customizations from kg to ton relying on the existing production base and equipment.

Manufacturing Unit is equipped with a facility of progressive reeducation of emissions, effluents and discharge of waste material that are known to have a negative impact on the environment. Besides, Laboratory as well as plant is equipped with latest Machinery, Equipments, Technical personnel & Means of communications.

Due to supply of reliable quality, efficient follow up, scheduled delivery and prompt response to any matter, company wins good comments from customers.

We aimed at delivering real business value to our clients. For any interest, pls call on us or email us to get our best services.

Company Info

  • Company Name: Taizhou Volsen Chemical Co., Ltd.
  • Representative: Mr Chen
  • Product/Service: Favipiravir Intermediates , Arbidol Intermediates , Relugolix Intermediates , Vilanterol Intermediates , Remdesivir Intermediates , Umeclidinium Bromide
  • Capital (Million US $): 60000000RMB
  • Year Established: 2002
  • Total Annual Sales Volume (Million US $): Above US$100 Million
  • Export Percentage: 91% - 100%
  • Total Annual Purchase Volume (Million US $): Below US$1 Million
  • No. of Production Lines: 5
  • No. of R&D Staff: 91 -100 People
  • No. of QC Staff: 11 -20 People
  • OEM Services Provided: yes
  • Factory Size (Sq.meters): 30,000-50,000 square meters
  • Factory Location: Dongying Economic Development Zone , Dongying, Shandong,China
  • Contact Person: Ms. Amy Cheng
  • Tel: 86-576-88869393
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